Queens on the Run follows ten Brazilian drag artists from across the country in a competition for the title of “Supreme Drag” as they travel to multiple Brazilian cities on a extravagantly decorated bus. Xuxa Meneghel, the most famous Brazilian television entertainer, and Ikaro Kadoshi, one of the most respected Brazilian drag queens, are the hosts. In the show, the participants face different challenges inspired by the cultural traditions of each city the bus passes through. The competition also has a judging panel composed by the hosts and special guests. At the end of each episode, one of the queens is eliminated until the finalists remain.