Several years ago, the Bugster Virus had infected humanity and turned its victims into monsters known as Bugsters. To combat this, the Japanese Ministry of Heath worked with the gaming company Genm Corp. to found Cyber Rescue, a team of young doctors with the ability to transform into Kamen Riders that can effectively eliminate Bugsters. However the CEO of Genm Corp. has his own ulterior motives for doing this as he becomes an antagonist to our heroes.