After the founding of New China, in order to support socialist construction, He Changsheng moved his family from Jiangdu, Yangzhou, to Huainan, Anhui, and took root on the banks of the Huaihe River. In the next twenty years, He Changsheng had six daughters in a row, but died in a car accident. The eldest sister He Jiali, her grandmother He Wenshi, and her mother Liu Meixin shouldered the burden of the family and arranged for the younger sisters to start a family and start a business. Times are changing, and the six sisters of the He family have also experienced the ups and downs of marriage, work, and life. However, they are united and face the ups and downs of life together. In the trials of life, the six sisters finally understand what their father repeatedly emphasized before his death. the meaning of "home".