Successful doctor Ramsey gives up everything to pursue a private vendetta he knows he can't win, against forces he can't fully know. His nemesis is Lambert, ruthless principal of a powerful European drug smuggling cartel. Personal tragedy and simple private heroism develop into a pursuit from which there could be no retreat. Echoes of Holmes and Moriarty leading to Reichenbach Falls, but brutally modern. Sub-themes of the miniseries are the nature of addiction and the unspoken pact between user and supplier against those who really care, and the pitfalls in attempting to break that collaboration.