Stephen Fry presents this documentary exploring the disease of manic depression; a little understood but potentially devastating condition affecting an estimated two percent of the population. Stephen embarks on an emotional journey to meet fellow sufferers, and discuss the literal highs and lows of being bi-polar. Celebrities such as Carrie Fisher and Richard Dreyfuss invite the comedian into their home to relate their stories. Plus Stephen looks into the lives of ordinary people trying to deal with the illness at work and home, and of course to the people studying manic depression in an effort to better control it. A fascinating, moving and ultimately very entertaining Emmy Award-winning program.