The miniseries tells the story of Nanà, whose life changes forever when her daughter Sara suddenly falls ill with leukemia. The discovery of other similar cases makes her guess that her cause lies in the fine particles emitted by Ghisal, a steel mill where her husband Sergio has been working for twenty years. Flanked by the journalist Stefano, Nanà fights for the truth to come out, first involving the other mothers and then the whole community.