Via the Biggest, Most Awful, Most Tragic Event in Human History, Super High School Level Despair has driven the former world to destruction. In order to save this despair-soaked world, the Future Foundation was formed. Makoto and his fellow Class 78th classmates, having defeated Junko Enoshima, have joined the Future Foundation. There they are working to rebuild the world, but Makoto has been charged with the crime of treason for protecting the Remnants of Despair. Everyone who gathered for Makoto's trial has been trapped and thrust into the “Final Killing Game” by Monokuma. Everyone is fitted with a strange bracelet that releases a sleeping potion at a fixed time. While asleep, the traitor in their midst kills a Future Foundation member. To survive, they'll have to ferret out the traitor and stop the killing. The class trial rules do not apply to this killing game. Makoto and the others have been driven into a desperate kill or be killed situation. The tale of hope and the despair that kills hope begins now.