Manuela is a beautiful young woman who works alongside her boyfriend, Mateo, at the radio station in her town. But upon learning of the murder of her parents, she decides to leave and forget everything that causes her resentment, including leaving her boyfriend aside. Manuela arrives in the city and stays at her uncle's house, but she is not very well received. Her cousin Cristina hates her and envies her for her beauty, which she attracts a millionaire, Francisco Grijalba. Over time, Manuela becomes Francisco's wife, but she discovers very late that she lives next to a sick, psychopathic and obsessive man who will make her life impossible. Meanwhile Mateo, who is now a renowned singer, does not stop looking for Manuela, but her attempts are unsuccessful and he decides to forget her; Although she holds a grudge against him. Manuela will have to take risks in order not to lose that true love, even if her destiny shuffles against her.