Chief Physician Barış Güvener is appointed to Hisarönü Hospital, one of the oldest and most established hospitals in Istanbul. However, Hisarönü, one of the best hospitals of its time, is going through a difficult time. With the arrival of a young and idealistic chief physician, the story of the entire hospital begins to be rewritten. As Barış tries to get the hospital up and running, he will not only struggle with the difficulties in his own life but also enter into a tough battle for his patients along with his colleagues, whose hearts he wins one by one. While the path of impossible loves, precious friendships, and touching life stories passes through Hisarönü Hospital, Barış will make us believe again in the power of love, hope, and devotion and will open the doors of the hospital to everyone living in Istanbul!