The Best of Youth is a family saga set in Italy from 1966 through 2003. It chronicles the life of an Italian family, the Caratis, but focuses primarily on two brothers, Matteo (Alessio Boni) and Nicola (Luigi Lo Cascio), documenting their journey from the prime of their wild youth in the mid-1960s counterculture, to parenthood and retirement in the early 2000s. The film aims to show the interaction of the personal and the political, the ways in which small events may become turning points in the important choices made by individuals.